Which signs indicate possible liver damage from Depakote therapy?

• A. Jaundice, clay-colored stools, dark urine
• B. Increased appetite
• C. Hair growth
• D. Improved energy

Answer: (A)

Recognizing signs of potential liver damage from Depakote involves knowing the classic early indicators of hepatotoxicity. Jaundice (yellowing of the skin or eyes), clay-colored stools, and dark urine point to problems with bilirubin processing and bile flow, which can occur with valproate therapy. If these symptoms appear, they require prompt medical evaluation because they signal possible liver injury. Other options like increased appetite, hair growth, or improved energy do not indicate liver damage and are not typical warning signs of hepatotoxicity.