Which of the following is considered a serious potential side effect of Depakote?

• A. Suicidal thoughts or self-injury
• B. Hair growth
• C. Increased appetite
• D. Mild dry skin

Answer: (A)

Depakote can affect mood and behavior in some people, so a major safety concern is the emergence of suicidal thoughts or self-injury. This is why clinicians emphasize monitoring for new or worsening mood changes, agitation, or thoughts of harming oneself, especially when starting the medicine or adjusting the dose. If such thoughts occur, contact a healthcare provider right away and seek urgent help if there’s a plan or imminent danger. The other options—hair growth, increased appetite, and mild dry skin—can happen but are not considered serious safety risks in the same way; they’re typically milder or cosmetic.