Prader-Willi syndrome is most closely associated with obesity risk due to

• A. Chronic hunger and obesity risk
• B. Lack of appetite and underweight
• C. Excess insulin production
• D. Low hunger and obesity resistance

Answer: (A)

Prader-Willi syndrome disrupts how the brain regulates hunger, so people experience a persistent, insatiable drive to eat. That lifelong hyperphagia, if not tightly controlled, leads to rapid weight gain and a high risk of obesity. The body’s fullness signals are blunted and hunger signals heightened, with some individuals showing elevated ghrelin levels, the hormone that stimulates appetite. So the obesity risk comes from chronic hunger and the resulting excessive intake, not from a lack of appetite, excessive insulin as the primary cause, or any resistance to hunger.